白丝avI亚洲一级影片I泽村玲子在线I日韩色吧I爱情岛论坛永久入口I欧美精品久久久I毛片a级免费I深夜福利免费看I大学生一级一片全黄I国产精品一区二区三区久久久I国产精品久久久久无码avI丰腴饱满的极品熟妇I2018天天干天天操I95看片淫黄大片一级I欧美尤物videos顶级I国产午夜视频I学生孕妇videosex性欧美Icaoporn超碰进入18I不卡视频在线观看I中文字幕在线2018I一本久道在线I国产精品天天看I国产日韩精品一区I中文在线观看免费网站I97人人超I日韩欧美一二区I亚洲精品国产精品乱码桃花

IL18 binding protein binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18 induced IFN gamma production. It is constitutively expressed and secreted in mononuclear cells and can be enhanced by IFN gamma. An elevated level of this protein is detected in the intestinal tissues of patients with Crohn disease. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS gene

NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [

Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting c